Cherry leaves contain many compounds, namely flavonoids, tannins, saponins, phenolics, steroids, and alkaloids. One of the compounds that act as an antibacterial is the flavonoid compound. One of the uses of cherry leaves is anti-acne. Acne is a chronic inflammatory disease of the pilosebaceous glands. One of the bacteria that causes acne is Propionibacterium acnes bacteria. Preparations that can be made for anti-acne are gel preparations. This study aims to determine whether the n-hexane fraction of cherry leaf (Muntingia calabura L.) can be made into anti-acne gel preparations and to find out at what concentration the n-hexane fraction of cherry leaf (Muntingia calabura L.) in anti-acne gel preparations can provide antioxidant activity. inhibiting the growth of Propionibacterium acnes bacteria.