The 1st Spring Virtual Meeting on Medicinal Chemistry was held virtually on 26 May 2021. The event was organized by the Medicinal Chemistry Division of the Portuguese Chemical Society (SPQ) and was endorsed by the European Federation for Medicinal Chemistry and Chemical Biology. Three plenary lectures were delivered by renowned international scientists, and seven oral communications were presented by young researchers to a significant number of attendees of 20 nationalities. This issue presents the proceedings of this meeting in the form of abstracts for papers presented at the conference