Recurrent Aftose Stomatitis (RAS) or sprue is one of the most common diseases of the oral mucosa. One of
the contributing factor is the infection of Streptococcus sanguinis and Candida albicans. Black betel leaf
contains a group of secondary metabolites that are used as antimicrobials . Gel is a good conductive
preparation on mucouse membran. One of the factors that influence the physical properties of gel is the
gelling agent. The purpose of this study was to determine the effect of HEC variation as a gelling agents on
the physical properties of black betel leaf extract gel. Black betel leaf extract was obtained by maceration
with 70% ethanol solvent. The gel was formulated into four formula with variations in HEC consentration
is 1%, 1,5%, 2% and 2,5%. The antimicrobial activity of the extracts used the diffusion method of the
wells. Tests of physical properties used organoleptic tests, homogenity, pH, spreadability and viscosity. The
results showed that black betel leaf extract at a concentration of 2.5% was able to inhibit Streptococcus
sanguinis and Candida albicans. An increase in HEC concentration can cause increase in the viscosity and
decrease in the spreadibility, but does not affect organoleptics, homogenity and pH of the preparation. The
best formula produced is formula F3 with 2% HEC composition