Kesum (Polygonum minus Huds) is one of the typical plants that grow in West Borneo The Kesum leaves are the part which is mostly used. Kesum leaves contain a lot of phytochemical compounds. This study quantitatively determined the total phenolic, flavonoid, and alkaloid contents in methanol and ethanolic extract of Polygonum minus Huds leaves using a spectrophotometric method. The samples were extracted by maceration. The content was determined by using a UV-Vis spectrophotometer. Based on the assay result, the methanol extract contained total of phenolic 49 351±0.430 ppmEAG (equivalent to gallic acid), total of flavonoids 44.128±0.116ppmEQ (quercetin equivalent): total of alkaloids 356,798±1,004ppmEP (piperine equivalent) The 96% ethanol extract contained total of phenol 46.196±0.329ppmEAG; total of flavonoids 34,969±0.116ppmEQ, total of alkaloids 183.525±0.766ppmEP The 70% ethanol extract contained total of phenol 64.189+0.215ppmEAG: total of flavonoids 27.834±0.158ppmEQ; total of alkaloids 432,947±1,533ppmEP. The ethanol extract 50% contained total of phenol 67,343±0.164ppmEAG; total of flavonoids 26.063±0.158ppmEQ, total of alkaloids. 679,142±2,525ppmEP. All of the results are preliminary data for further research, especially for the isolation of compounds with specific targets or for utilization as main ingredients for traditional medicine Keywords: Polygonum minus Huds, phenols; flavonoids, alkaloids, different solvents.