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UJI EFEKTIVITAS ANALGETIK KOMBINASI EKSTRAK ETANOL RUMPUT TEKI (Cyperus rotundus L.) DAN EKSTRAK ETANOL DAUN TAPAK LIMAN (Elephantopus scaber L.) PADA MENCIT PUTIH GALUR SWISS DENGAN METODE PAW PRESSURE TEST
Pain is unconfoteble condition of the body caused by a strong or destructive
stimulation. The nut grass plant (Cyperus rotundus L.) contains flavonoids that have
the potential to relieve pain, while the leaves of tapak liman (Elephantopus scaber L.)
have previously been conducted research that these plants have analgesic activity in
pain. The purpose of this study was to determine the effectiveness of the analgesic
effect of the combination of the ethanol extract of nut grass (Cyperus rotundus L.)
with the ethanol extract of tapak liman leaves (Elephantopus scaber L.) on male
mice.
This research is a laboratory experimental research. The test animals were divided
into 6 groups @ 5 male mice. Normal controls were given CMC Na 0.5%, negative
controls were not given any treatment, only given pain stimulation, positive control
was given paracetamol at a dose of 63 mg/kg body weight, for treatment group I was
given ERTDTL at a dose of 700 mg/400 mg/kg body weight, for treatment group II
was given ERTDTL with a dose of 900mg/600mg/kgBW, while group III was given
ERTDTL at a dose of 1100g/800mg/kgBW. The data obtained are in the form of time
when mice respond to pain stimuli given by pulling their legs or making sounds, then
the Kruskal Wallis analysis test. Kruskal Wallis analysis was expressed in terms of
mean±SD, where the test results were significant if p 0.05. Further analysis of the
independent sample T-test was carried out with a 95% confidence level.
The results showed that giving a combination of ethanol extractfrom teki grass and
tapak liman leaves (ERTDTL) at a dose of 700mg/400mg/kgBB, 900mg/600mg/kgBB
and 1100mg/800mg/kgBB had analgesic activity against white Swiss strain mice that
were given pain stimulation using paw pressure test method
Key words: Analgesics, nut grass, tapak liman leaves, Paw pressure test,
Randalll selitto.
Ketersediaan
KTI000719 | 615.4 BAY U | My Library | Tersedia |
Informasi Detail
Judul Seri |
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No. Panggil |
615.4 BAY U
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Penerbit | STIFERA : SEMARANG., 2021 |
Deskripsi Fisik |
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Bahasa |
Indonesia
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ISBN/ISSN |
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Klasifikasi |
615.4 BAY U
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Tipe Isi |
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Tipe Media |
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Tipe Pembawa |
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Edisi |
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Subjek |
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Info Detail Spesifik |
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Pernyataan Tanggungjawab |
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